Francisco Javier Blanco López

Francisco Javier Blanco López
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Profesor Contratado Doctor Indefinido

Departamento de Bioquímica y Biología Molecular IIi e Inmunología
Facultad de Medicina
Avenida Doctor Jesús Candel Fábregas nº 11 18071 Granada
958240731
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Coordinador del Programa de Doctorado En Biomedicina

Escuela Internacional de Posgrado
Escuela Internacional de Posgrado
Avenida de Madrid nº 13 18071 Granada
958240731
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Tutorías

Día
Horario
Lugar
Lunes
9:30 - 11:30
Facultad Medicina C10 - 03
Miércoles
9:30 - 11:30
Facultad Medicina C10 - 03
Viernes
9:30 - 11:30
Facultad Medicina C10 - 03

Docencia

Grado en Biología

Inmunología

Grado en Bioquímica

Inmunología Clínica

Grado en Biotecnología

Inmunología
Vacunas y Adyuvantes

Grado en Farmacia

Inmunología

Grado en Medicina

Inmunología

Máster Universitario en Investigación y Avances en Inmunología Molecular y Celular

Módulo de Inmunología Molecular y Celular - Activación y Muerte Celular en el Sistema Inmunohemátopoyetico
Módulo de Inmunología Molecular y Celular - Metodología en Biologia Molecular y Celular

Investigación

  1. Diálogo molecular entre macrófagos y la vasculatura mediado por miRNAs exosomales.
  2. Bases moleculares de la telangiectasia hemorrágica hereditaria (HHT, síndrome de Rendu).

Other data

  1. Carrillo-Rodríguez P, Robles-Guirado JÁ, Cruz-Palomares A, Palacios-Pedrero MÁ, González-Paredes E, Más-Ciurana A, Franco-Herrera C, Ruiz-de-Castroviejo-Teba PA, Lario A, Longobardo V, Montosa-Hidalgo L, Pérez-Sánchez-Cañete MM, Corzo-Corbera MM, Redondo-Sánchez S, Jodar AB, Blanco FJ, Zumaquero E, Merino R, Sancho J, Zubiaur M. Extracellular vesicles from pristane-treated CD38-deficient mice express an anti-inflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these mice. Front Immunol. 2022 Oct 24;13:1013236. doi: 10.3389/fimmu.2022.1013236. eCollection 2022. PubMed PMID: 36353645.
  2. Pozo-Agundo A, Villaescusa N, Martorell-Marugán J, Soriano O, Leyva S, Jódar-Reyes AB, Botella LM, Carmona-Sáez P, Blanco FJ. Identification of Exosomal MicroRNA Signature by Liquid Biopsy in Hereditary Hemorrhagic Telangiectasia Patients. Int J Mol Sci. 2021 Aug 31;22(17):9450. doi: 10.3390/ijms22179450. PubMed PMID: 34502358.
  3. Aristorena M, Gallardo-Vara E, Vicen M, de Las Casas-Engel M, Ojeda-Fernandez L, Nieto C, Blanco FJ, Valbuena-Diez AC, Botella LM, Nachtigal P, Corbi AL, Colmenares M, Bernabeu C. Human endoglin as a potential new partner involved in platelet-endothelium interactions. MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells. Int J Mol Sci. 2019 Jun 25;20(12):3107. doi: 10.3390/ijms20123107. PubMed PMID: 31242676.
  4. Rossi E, Pericacho M, Bachelot-Loza C, Pidard D, Gaussem P, Poirault-Chassac S, Blanco FJ, Langa C, González-Manchón C, Novoa JML, Smadja DM, Bernabeu C. Human endoglin as a potential new partner involved in platelet-endothelium interactions. Cell Mol Life Sci. 2018 Apr;75(7):1269-1284. doi: 10.1007/s00018-017-2694-7.PubMed PMID: 29080903.
  5. Ojeda-Fernández L, Recio-Poveda L, Aristorena M, Lastres P, Blanco FJ, Sanz-Rodríguez F, Gallardo-Vara E, de las Casas-Engel M, Corbí Á, Arthur HM, Bernabeu C, Botella LM. Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response. PLoS Genet. 2016 Mar 24;12(3):e1005935. doi:10.1371/journal.pgen.1005935. PubMed PMID:27010826; PubMed Central PMCID:PMC4806930.
  6. Gallardo-Vara E, Blanco FJ, Roqué M, Friedman SL, Suzuki T, Botella LM, Bernabeu C. Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis. 2016 Apr;19(2):155-71. doi: 10.1007/s10456-016-9495-8. PubMed PMID:26850053; PubMed Central PMCID: PMC4819519.
  7. Blanco FJ, Deng L, Stevens H, Lu R, Caudrillier A, McBride M, McClure JD, Grant J, Thomas M, Frid M, Stenmark K, White K, Seto AG, Morrell NW, Bradshaw AC, MacLean MR, Baker AH. MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial Hypertension. Circ Res. 2015 Oct 23;117(10):870-83. doi: 10.1161/CIRCRESAHA.115.306806. PubMed PMID: 26311719; PubMed Central PMCID: PMC4620852.
  8. Blanco FJ, Ojeda-Fernandez L, Aristorena M, Gallardo-Vara E, Benguria A, Dopazo A, Langa C, Botella LM, Bernabeu C. Genome-wide transcriptional and functional analysis of endoglin isoforms in the human promonocytic cell line U937. J Cell Physiol. 2015 Apr;230(4):947-58. doi: 10.1002/jcp.24827. PubMed PMID: 25216259.
  9. Aristorena M, Blanco FJ, de Las Casas-Engel M, Ojeda-Fernandez L, Gallardo-Vara E, Corbi A, Botella LM, Bernabeu C. Expression of endoglin isoforms in the myeloid lineage and their role during aging and macrophage polarization. J Cell Sci. 2014 Jun 15;127(Pt 12):2723-35. doi: 10.1242/jcs.143644. PubMed PMID:24777481.
  10. Valbuena-Diez AC, Blanco FJ, Oujo B, Langa C, Gonzalez-Nuñez M, Llano E, Pendas AM, Díaz M, Castrillo A, Lopez-Novoa JM, Bernabeu C. Oxysterol-induced soluble endoglin release and its involvement in hypertension. Circulation. 2012 Nov 27;126(22):2612-24. doi: 10.1161/CIRCULATIONAHA.112.101261. PubMed PMID:23110859.
  11. Rossi E, Sanz-Rodriguez F, Eleno N, Düwell A, Blanco FJ, Langa C, Botella LM, Cabañas C, Lopez-Novoa JM, Bernabeu C. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood. 2013 Jan 10;121(2):403-15. doi: 10.1182/blood-2012-06-435347. PubMed PMID: 23074273.
  12. Garrido-Martín EM, Blanco FJ, Roquè M, Novensà L, Tarocchi M, Lang UE, Suzuki T, Friedman SL, Botella LM, Bernabéu C. Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene. Circ Res. 2013 Jan 4;112(1):113-27. doi: 10.1161/CIRCRESAHA.112.275586. PubMed PMID: 23048070; PubMed Central PMCID: PMC3537907.
  13. Blanco FJ, Bernabéu C. The Splicing Factor SRSF1 as a Marker for Endothelial Senescence. Front Physiol. 2012 Mar 28;3:54. doi: 10.3389/fphys.2012.00054. PubMed PMID: 22470345; PubMed Central PMCID: PMC3314196.
  14. Alt A, Miguel-Romero L, Donderis J, Aristorena M, Blanco FJ, Round A, Rubio V, Bernabeu C, Marina A. Structural and functional insights into endoglin ligand recognition and binding. PLoS One. 2012;7(2):e29948. doi:10.1371/journal.pone.0029948. PubMed PMID: 22347366; PubMed Central PMCID:PMC3275592.
  15. Blanco FJ, Bernabeu C. (2012). Alternative Splicing in Endothelial Senescence: Role of the TGF-ß Co-Receptor Endoglin, Senescence (chap. 20), Dr. Tetsuji Nagata (Ed.), ISBN: 978-953-51-0144-4, InTech.
  16. Damjanovich K, Langa C, Blanco FJ, McDonald J, Botella LM, Bernabeu C, Wooderchak-Donahue W, Stevenson DA, Bayrak-Toydemir P. 5'UTR mutations of ENG cause hereditary hemorrhagic telangiectasia. Orphanet J Rare Dis. 2011 Dec 22;6:85. doi: 10.1186/1750-1172-6-85. PubMed PMID: 22192717; PubMed Central PMCID: PMC3277489.
  17. Rossi E, Langa C, Gilsanz A, Blanco FJ, Ayllón J, Villar E, Botella LM, Cabañas C, Shaw M, Bernabeu C. Characterization of chicken endoglin, a member of the zona pellucida family of proteins, and its tissue expression. Gene. 2012 Jan 1;491(1):31-9. doi: 10.1016/j.gene.2011.09.010. PubMed PMID: 21982971.
  18. Blanco FJ, Bernabeu C. Alternative splicing factor or splicing factor-2 plays a key role in intron retention of the endoglin gene during endothelial senescence. Aging Cell. 2011 Oct;10(5):896-907. doi:10.1111/j.1474-9726.2011.00727.x. PubMed PMID: 21668763.
  19. Sierra-Filardi E, Puig-Kröger A, Blanco FJ, Nieto C, Bragado R, Palomero MI, Bernabéu C, Vega MA, Corbí AL. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood. 2011 May 12;117(19):5092-101. doi:10.1182/blood-2010-09-306993. PubMed PMID: 21389328.
  20. Garrido-Martin EM, Blanco FJ, Fernandez-L A, Langa C, Vary CP, Lee UE, Friedman SL, Botella LM, Bernabeu C. Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1. BMC Mol Biol. 2010 Jun 29;11:51. doi:10.1186/1471-2199-11-51. PubMed PMID: 20587022; PubMed Central PMCID: PMC2906440.
  21. Cristóbal I, Blanco FJ, Garcia-Orti L, Marcotegui N, Vicente C, Rifon J, Novo FJ, Bandres E, Calasanz MJ, Bernabeu C, Odero MD. SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia. Blood. 2010 Jan 21;115(3):615-25. doi:10.1182/blood-2009-06-227363. PubMed PMID: 19965692.
  22. Blanco FJ, Grande MT, Langa C, Oujo B, Velasco S, Rodriguez-Barbero A, Perez-Gomez E, Quintanilla M, López-Novoa JM, Bernabeu C. S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology. Circ Res. 2008 Dec 5;103(12):1383-92. doi: 10.1161/CIRCRESAHA.108.176552. PubMed PMID: 18974388.
  23. Fontalba A, Fernandez-L A, García-Alegria E, Albiñana V, Garrido-Martin EM, Blanco FJ, Zarrabeitia R, Perez-Molino A, Bernabeu-Herrero ME, Ojeda ML, Fernandez-Luna JL, Bernabeu C, Botella LM. Mutation study of Spanish patients with hereditary hemorrhagic telangiectasia. BMC Med Genet. 2008 Aug 1;9:75. doi: 10.1186/1471-2350-9-75. PubMed PMID: 18673552; PubMed Central PMCID: PMC2518546.
  24. Blanco FJ, Santibañez JF, Garrido-Martin EM, Sanz-Rodriguez F, del Pozo MA, Bernabeu C. Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae. Cardiovasc Res. 2008 Mar 1;77(4):791-9. PubMed PMID: 18065769.
  25. Blanco FJ, Llorca O, Trujillo A, Bernabeu C. Structural model of human endoglin, a transmembrane receptor responsible for hereditary hemorrhagic telangiectasia. J Mol Biol. 2007 Jan 19;365(3):694-705. PubMed PMID: 17081563.
  26. Fernández-L A, Sanz-Rodriguez F, Blanco FJ, Bernabéu C, Botella LM. Hereditary hemorrhagic telangiectasia, a vascular dysplasia affecting the TGF-beta signaling pathway. Clin Med Res. 2006 Mar;4(1):66-78. Review. PubMed PMID: 16595794; PubMed Central PMCID: PMC1435660.
  27. Muñoz-Fernández R, Blanco FJ, Frecha C, Martín F, Kimatrai M, Abadía-Molina AC, García-Pacheco JM, Olivares EG. Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts. J Immunol. 2006 Jul 1;177(1):280-9. PubMed PMID: 16785523.
  28. Blanco FJ, Santibanez JF, Guerrero-Esteo M, Langa C, Vary CP, Bernabeu C. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J Cell Physiol. 2005 Aug;204(2):574-84. PubMed PMID: 15702480.
  29. García-Pacheco JM, Oliver C, Kimatrai M, Blanco FJ, Olivares EG. Human decidual stromal cells express CD34 and STRO-1 and are related to bone marrow stromal precursors. Mol Hum Reprod. 2001 Dec;7(12):1151-7. PubMed PMID: 11719592.